Electrical impedance spectroscopy (EIS) is entering the genomic space. A new study, “DNA Concentration and Purity Characterization Through Nanotechnology-Assisted Bioimpedance,” highlights how multifrequency impedance, enhanced by magnetic nanoparticles, enables rapid, label-free DNA concentration and purity analysis with Sciospec technology at its core.
The research group employed Sciospec’s impedance measurement technology to perform high-precision measurements across a broad frequency range, enabling them to differentiate between DNA concentrations with improved reliability.
*Alcántar-Jacobo, M. Y., Ruiz-Romero, J. A., López-Madrigal, J. E., Arias-González, L., Sánchez-Monroy, V., & González-Díaz, C. A. DNA Concentration and Purity Characterization Through Nanotechnology-Assisted Bioimpedance. Springer Nature (2024). https://link.springer.com/chapter/10.1007/978-3-031-91774-5_6
This research introduces a novel, non-destructive method for DNA concentration and purity analysis that leverages electrical properties inherent to DNA and its interaction with surrounding media. By applying multifrequency bioimpedance spectroscopy, the team was able to capture a detailed electrical signature of DNA samples. Crucially, the addition of magnetic nanoparticles acted as signal enhancers helping to amplify the measurable differences between samples with different DNA concentrations.
The researchers used Sciospec’s high-resolution impedance technology to acquire data across a range of frequencies enabling them to build impedance profiles directly tied to DNA presence and quality.
The outcome is a measurement technique that’s rapid, scalable, and label-free, making it a compelling alternative or complement to existing bioanalytical techniques.
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A key enabler of this work was Sciospec’s impedance analysis technology, which served as the measurement platform for capturing multifrequency bioimpedance spectra. When working with complex biological precision, frequency range, and signal stability are critical and this is exactly where the Sciospec system demonstrated its value.
The researchers needed to capture subtle changes in impedance caused by differences in DNA concentration and interactions with magnetic nanoparticles.
Sciospec ISX-3’s technology, referenced and used in the study, delivered the required performance helping transform a theoretical approach into a validated experimental process. The impedance measurements served as the foundation for the study’s conclusions, and the quality of this data was only possible through a robust and sensitive measurement platform.
🔍 Looking for more answers ? Check out our detailed FAQ section further down to see how our solutions supports bioimpedance-based DNA sensing with unmatched performance
At the heart of the system used in this study is Sciospec’s ISX-3 Impedance Analyzer, a powerful, flexible platform specifically designed for advanced electrical impedance spectroscopy applications. The ISX-3 is ideally suited for biological, chemical, and material analysis where sensitivity and flexibility are required.
Key benefits of the ISX-3 for bioimpedance-based DNA studies include:
For researchers developing next-generation biosensors or molecular diagnostic tools, the ISX-3 provides a precise, user-friendly, and scalable platform for exploring the role of electrical impedance in biomolecular analysis.
📚 Explore how the ISX-3 has enabled similar breakthroughs in DNA quantification.
🔗 Read the related publication and discover the system’s role in nanoparticle-enhanced bioimpedance sensing.
One of the ISX-3’s key advantages is its modular scalability. For applications requiring parallel measurement of multiple samples, such as high-throughput screening, biosensor array testing, or multi-well microfluidic analysis, the ISX-3 can be equipped with multiplexers supporting 32 or 64 channels, with the option to scale further upon request.
This capability is crucial for research groups or diagnostic developers aiming to move from individual experiments to automated, large-scale sample testing.
With multiplexing, the ISX-3 becomes not just a measurement tool, but a scalable bioimpedance platform ready for integration into industrial R&D workflows or preclinical assay development pipelines.
📈 Discover how integrating multiplexers can enhance throughput and efficiency in impedance-based analytics. Explore multiplexing options for the ISX-3
ISX-3 for Clinical Research and Medical Diagnostics Applications
For applications situated within medical diagnostics, clinical research, or in-vitro assay development under stricter regulatory contexts, Sciospec offers a Medical Research version of the ISX-3. This variant maintains all the core technical capabilities of the standard ISX-3 while offering:
This makes it ideal for collaborations with hospitals, medicine labs, and diagnostic startups working toward clinical applications where compliance matters.
🏥 Evaluate how the Medical Research ISX-3 can accelerate your clinical development pipeline.
🔬 See technical details and clinical use features
Our experts are ready to help you understanding how this technology works and how you can apply and integrate it into your work. Get in touch today to get a personalized consultation to enhance your work with our advanced solutions
Bioimpedance refers to the measurement of the electrical impedance of biological material. In DNA analysis, it can be used to detect changes in electrical properties caused by variations in DNA concentration or purity, offering a label-free and non-destructive method for biomolecular characterization.
💡The Sciospec ISX-3 Impedance Analyzer’s high precision and broad frequency range make it especially effective for capturing these subtle bioimpedance changes in DNA samples.
Electrical impedance spectroscopy works by applying an alternating current over a range of frequencies and measuring how a sample resists or reacts to it. In molecular diagnostics, EIS can help identify molecular interactions or detect biomolecules like DNA based on their distinct electrical signatures.
💡The ISX-3 system’s stable signal and wide frequency coverage enhance the detection of these molecular signatures, improving diagnostic reliability.
Magnetic nanoparticles enhance signal sensitivity in impedance-based biosensing by interacting with target biomolecules such as DNA. They alter the local electrical environment, making it easier to distinguish between samples with varying concentrations or properties.
💡The ISX-3 is engineered to handle nanoparticle-enhanced bioimpedance measurements, providing the sensitivity and flexibility required for this advanced application.
Yes, when performed with high-resolution equipment and appropriate calibration, impedance spectroscopy can provide accurate, repeatable measurements of DNA concentration and purity. It offers advantages over traditional techniques due to its speed, sensitivity, and label-free nature.
💡Thanks to its measurement accuracy of 0.01%, the ISX-3 enables highly precise DNA quantification critical for research and clinical use.
Electrical impedance can serve as a complementary or alternative method to UV absorbance for DNA purity assessment. It is particularly useful when non-invasive or real-time measurements are required and when sample volume is limited.
💡The ISX-3’s plug-and-play compatibility with microfluidic biochips allows rapid, non-destructive DNA purity assessments without large sample volumes.
Non-invasive DNA analysis techniques like impedance spectroscopy minimize sample consumption, reduce preparation time, and allow for real-time or in-situ monitoring. This is especially valuable in sensitive or high-throughput applications.
💡 The ISX-3’s modular hardware adapters and multiplexing options make it ideal for scaling non-invasive DNA analysis in both research and industrial workflows.
The frequency range determines which molecular or structural components are probed in bioimpedance measurements. Low frequencies may capture bulk properties, while higher frequencies can reflect interfacial or membrane-related phenomena—crucial for detailed DNA or biosensor analysis.
💡 The ISX-3 covers an extensive frequency spectrum from 100 µHz to 100 MHz, enabling comprehensive analysis of DNA and nanoparticle interactions across multiple scales.
The publication highlights how electrical impedance spectroscopy, when paired with innovative materials like magnetic nanoparticles, can offer a powerful, label-free approach to DNA sensing. The success of the method gives not only on experimental design but also on the quality of the impedance data, a challenge met by Sciospec’s instrumentation.
As research in bioimpedance-based molecular sensing accelerates, the ISX-3 provides a versatile and dependable platform to support discovery, prototyping, and even scalable testing.
🚀 Ready to integrate EIS into your DNA analysis or biosensing application?
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#Innovation #Sciospec #Multifrequency bioimpedance #Bioimpedance spectroscopy #Noninvasivebiomolecularanalysis #DNAquantification
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