In the study “Purification of Genetic Material Concentration from Dental Samples Using EBiS Assisted with MNPs,” researchers start with discarded teeth, extract the DNA purify it using magnetic nanoparticles (MNPs) and use a Sciospec ISX-3 Impedance Analyzer to assess purification quality.
Instead of relying on optical stains and multi-step protocols, the ISX-3 performs a quick frequency sweep enabling rapid electrical quality control. Powered by the same multi-frequency precision trusted in bioimpedance labs worldwide the result is used to validate purification success in real time.
*Alcántar-Jacobo, M.Y., González-Hernández, M., Pérez-Vázquez, A.E., Lozano-Trenado, M.L., Ruiz-Romero, J.A., Sánchez-Monroy, V., & González-Díaz, C.A. Purification of genetic material concentration from dental samples using EBiS assisted with MNPS. IOP Publishing Ltd (2024). https://iopscience.iop.org/article/10.1088/1742-6596/3014/1/012008
Traditional DNA analysis often involves multiple manual steps and long wait times especially when working with small or sensitive samples like dental tissue. In contrast, this study highlights how Sciospec’s ISX-3 Impedance Analyzer enables a faster, cleaner alternative by integrating Electrical Bioimpedance Spectroscopy (EBiS) directly into purification workflows.
Using this setup the researchers observed a consistent rise in reactance after purification evidence that cleaner DNA carries a distinct impedance signature. This aligns with earlier applications of Sciospec’s technology where bioimpedance and nanotechnology were combined for precise DNA characterization
🔍 Looking to streamline your DNA purification process? Contact Our experts to explore how the ISX-3 can be tailored to your specific samples and workflow needs
Successfully using Electrical Bioimpedance Spectroscopy (EBiS) with Magnetic Nanoparticles (MNPs) for DNA purification requires more than just an analyzer it takes smart design and tailored support. Here’s how Sciospec helped make this study’s approach practical and effective:
This combination of tailored hardware and software made it simple for researchers to track DNA quality without complex setup or delays.
🔍 Looking to simplify DNA workflows with label-free impedance measurements? Explore the ISX-3’s technical specs and application setups.
The Sciospec ISX-3 Impedance Analyzer is specially designed to support DNA analysis with magnetic nanoparticles by offering precise, efficient and gentle measurement capabilities:
Enables detection of subtle reactance changes that reflect DNA concentration shifts, even in small-volume or partially degraded samples typical of dental forensic evidence.
Covers the key frequency range where DNA and buffer signals are most distinct.
Prevents sample heating or nanoparticle clumping during measurements.
Together, these features help researchers perform fast, label-free, and reliable DNA purity checks with minimal sample handling.
📚 Discover the full technical specifications and how the ISX-3 can advance bioimpedance research.
For labs handling many DNA samples at once, the ISX-3 Multiplexer add-ons make it easy to expand testing capacity without extra hassle. Benefits include:
🔀 Test many samples in parallel: Connect up to 32 or 64 channels and check multiple DNA purification wells at the same time.
⚠️ Spot issues quickly: Batch data helps identify outliers before moving on to sequencing.
⏱️Run unattended workflows: Automated measurements can run overnight, delivering ready-to-review results by morning.
🧩Flexible and easy to use: Compact design with simple setup, adaptable to different sensor types and lab environments.
📈Want to learn more about how multiplexers can boost your lab’s efficiency?
Explore multiplexing options for the ISX-3
Our experts are ready to help you understanding how this technology works and how you can apply and integrate it into your work. Get in touch today to get a personalized consultation to enhance your work with our advanced solutions
Electrical Bioimpedance Spectroscopy (EBiS) is a technique that measures the electrical properties of biological samples across multiple frequencies. It provides detailed information about the composition and purity of genetic material like DNA without the need for chemical reagents or dyes.
🔬 Sciospec’s ISX-3 Impedance Analyzer leverages multi-frequency EBiS to deliver precise, label-free DNA quality assessments in real time—making it an efficient tool for research and diagnostics workflows.
Magnetic Nanoparticles (MNPs) are tiny magnetic beads that selectively bind to DNA molecules. They enable rapid isolation and purification of DNA from complex biological samples using magnetic fields, improving both yield and purity.
🔬 Sciospec supports MNP-based workflows through custom electrode designs and synchronized software integrationstreamlining the entire DNA purification and analysis process.
DNA purification removes inhibitors and contaminants, ensuring high-quality material for downstream analysis such as PCR or sequencing. For forensic and clinical applications, reliable results depend on pure, uncontaminated DNA.
🔬 With real-time, label-free analysis via the ISX-3 labs can assess DNA purity quickly and non-destructively minimizing sample loss and improving turnaround times.
By measuring the electrical response of DNA samples across different frequencies, multi-frequency bioimpedance reveals patterns that correlate with DNA concentration and purity. This enables quick, reagent-free assessments.
🔬 The ISX-3 performs precision frequency sweeps (100 Hz to 10 MHz) with stable phase accuracy supported by Sciospec’s data tools for streamlined interpretation of DNA quality.
Yes. EBiS combined with MNPs is ideal for forensic or low-volume biomedical samples like dental tissue, where preservation and efficiency are key. This technique reduces handling and preserves evidence integrity.
🔬 Sciospec’s micro-electrode designs allow sensitive impedance measurements in volumes below 5 µL making the ISX-3 perfectly suited for scarce or degraded sample types.
Impedance-based data complements optical and biochemical techniques, offering a more complete picture of DNA sample quality. Integration across platforms enhances accuracy and confidence in results.
🔬 Sciospec’s open data formats and automation-ready software support seamless integration with tools like UV-Vis spectrometers and magnetic bead platforms enabling multi-modal genomic quality control
The published findings confirm that multi-frequency EBiS, assisted by magnetic nanoparticles provides impedance measurements that correlate with DNA purification quality. For forensic scientists and biomedical researchers aiming to reduce consumables and turnaround times impedance spectroscopy offers a practical path forward.
🚀Ready to evaluate bioimpedance for your DNA or biomolecule assays?
🤝Reach out to our applications team to see how easily impedance readouts can plug into your existing purification pipeline
💡Curious for more? Check out our latest developments and products.
🧪Want to try it yourself? Contact us for more information
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