Biofilm formation can cause serious health hazards, mostly due to the uncontrolled release of pathogens. This can generate several problems in industrial facilities, e.g., in the food industry. The aim of the present study was to develop and implement a multi-parametric sensor system to monitor biofilm formation in laboratory as well as industrial set-ups. To minimize cross sensitivity or interference, the device was based on a combination of different measurement principles. Micro-organisms were initially cultivated in a laboratory scale reactor. Afterwards, biofilm formation will be studied with each prototype of the multi-parametric sensor followed by final tests on an industrial scale.