512 channel system for in-depth insights into complex cell electrophysiology

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Multichannel Potentiostat/Galvanostat topologies

There is a multitude of scenarios that demand more than one channel of a potentio-/galvanostat. The reasons vary greatly – just to name a few typical settings:

  • automating sequential multi-sensor probing over
  • the need of scaling up experiments to more throughput via parallel experiments
  • complex multi-electrode arrangements with need for specific synchronized control
  • simultaneous comparison of a single or a set of test targets/sensors to a single or a group of reference sensors

As diverse as the reasons for using multichannel arrangements are the choices for solutions. In general, there are four basic approaches:

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512 channel Potentiostat/Galvanostat for automated test and conditioning of electronic components

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Phenocor

The joint research project PhenoCor deals with the development of a medical diagnostic device (Clinical Multi Electrode Array, cMEA) for a better and more precise in-vitro stratifization, model-based therapy planning and clinical safety pharmacology for patients suffering from a genetically caused heart disease.

Our partners of the University of Leipzig and the University Clinic in Dresden are focusing on the assay and experimental design Sciospec`s role is to develop and build a massiv-multichannel system combining electro-physiological potential recording (EPR), electrical impedance spectroscopy (EIS), electrical impedance tomography (EIT) and complex stimulation within the same system. The system allows for fully simultaneous acquisition of impedance or potential signals on up to 512 electrodes in combination with up to 4 independent complex stimulation injections. This opens up new possibilities for monitoring highly dynamic and spatially distributed electro-physiological phenomena and allows in-depth insights into complex cell interactions. An application-specific sensor adapter brings together the measurement system and the newly designed high density sensor array with an innovative contacting scheme.

Find out more about the PCOR system.

 

PhenoCor is supported by the Free State of Saxony and the European Union (SMWA/EFRE).
Project number: 100387683

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